1、在项目中添加引用，Project > Add Reference > COM > Windows Script Host Object Model.

2、添加

using IWshRuntimeLibrary;
#region 创建快捷方式
WshShell wshShell = new WshShell();
string path = System.IO.Path.Combine(Environment.GetFolderPath(Environment.SpecialFolder.DesktopDirectory), "哈哈哈.lnk");
IWshShortcut shortcut = (IWshShortcut)wshShell.CreateShortcut(path);
shortcut.Description = "11111";
shortcut.TargetPath = Application.StartupPath + @"\OnlyRunOneEXE.exe";
 shortcut.Save();
#endregion

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