视网膜变性笔记-CFANZ编程社区

Comment: Retinal degeneration in rats and mice can occur as an aging change or secondary to
various insults, such as physical trauma, retinal detachment, inflammation, infectious agents (e.g.,
viruses), vascular derangements (e.g., infarction), increased intraocular pressure, and nutritional
deficiencies. Numerous heritable retinal degenerations have also been documented in various strains
of laboratory mice and rats. So-called light-induced retinal degeneration can occur when rats and mice
(especially albino strains) are exposed to overly intense ambient light. Retinal degeneration can also be
a direct toxic effect of systemically or topically administered chemical agents. Spontaneously occurring
retinal degeneration of uncertain etiology has also been reported in laboratory rats and mice. In many
types of retinal degeneration, the most commonly affected retinal neurons are the rod and cone
photoreceptors and/or the ganglion cells. Depending on the cause, degenerative changes may be
localized (or more extensive) in particular retinal topographic regions (i.e., superior vs. inferior, central
vs. peripheral).
Mild retinal degeneration (Figure 2, compare to Figure 1) typically consists of loss of the rod and cone
photoreceptor processes, apoptosis of outer nuclear layer photoreceptor cells, hypocellularity and
disorganization of the inner and outer nuclear layers, and narrowing or absence of the plexiform layers.
More pronounced retinal degeneration (Figure 3, compare to Figure 1) is typically characterized by【1】

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【2】中信息【1】中类似

提到了偶然的视网膜变性：

外周视网膜显著变薄

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本文结论：

特定层的细胞减少、视杆和视锥光感受器突起

视网膜退化类型中，最常见的视网膜神经元是视杆和视锥

光感受器和/或神经节细胞（这句话是重点）。根据病因，退行性改变可能会发生

局限（或更广泛）于特定视网膜地形区域（即，上下、中央

与外围设备）。

轻度视网膜变性（图2与图1相比）通常包括视杆和视锥的丧失